Keynote Speakers

Monday, 12 November @ 12:35 – 13:05

Session 1A2

Author: Chia-Fu Chou, Academia Sinica, Taiwan

Presentation Title:  Nanofluidics and dielectrophoresis based biosensors and analytical platforms: challenges and opportunities

Chia-Fu Chou received his B.S. in physics from National Tsing Hua University (Hsinchu) in 1986, and Ph.D. in physics from State University of New York at Buffalo in 1996. From 1997-2000, he was a NIH postdoctoral fellow at Princeton University (in physics and molecular biology). In 2000, he joined the Solid State Research Center of Motorola Labs in Tempe, AZ, as a Lead Scientist, and a Principal Staff Scientist in 2001. In late 2002, he co-founded the interdisciplinary Center for Applied Nanobioscience in the Biodesign Institute at Arizona State University, and served as an Associate Professor and Principal Investigator. Since Spring 2006, he has been a Senior Research Fellow (Professor) at Institute of Physics with affiliation at both Genomics Research Center and Research Center for Applied Sciences, Academia Sinica, Taipei, Taiwan. He has over 100 scientific publications and 12 issued (USA*9, Taiwan*2, EU*1) and several pending patents. He was the co-inventor of the electrodeless dielectrophoresis (or insulator-based dielectrophoresis), a notable technique known in the microfluidics community. His current research interests include single molecule and cell biophysics, nanobiosensing, micro- and nanofluidics, and bioimaging. During 2013-2016, he served on the Editorial Board of the AIP Journal Biomicrofluidics. In 2014, he chaired the 5th International conference of Advances of Microfluidics and Nanofluidics (AMN2014) held in Taipei and served as a guest editor of the special issue of Biomicrofluidics for AMN2014. In 2015, co-chaired Biophysical Society (USA) Thematic Meeting: New Biological Frontiers Illuminated by Molecular Sensors and Actuators, held in Taipei. He has presented over 60 invited talks in international and regional conferences. His research on nanoscale molecular dam (JACS Spotlight) and single DNA molecule tug-of-war (Nature Research Highlight) were selected as 2013 Academia Sinica Significant Research Achievements and he was awarded the Outstanding Research Award in 2014 from the Ministry of Science and Technology, Taiwan, ROC.

Session 1B2

Author: Jonathan Cooper, University of Glasgow, Scotland

Presentation Title: Origami Diagnostics – Low Cost DNA Sensing in Underserved Rural Communities

Professor Jon Cooper holds The Wolfson Chair in Biomedical Engineering and is Vice Principal leading the University’s strategy in Knowledge Exchange and Innovation. He is an EPSRC Leadership Research Fellow and holds a European Research Council Advanced Programme Grant. His major research interests are in medical diagnostics and imaging, with a track record of spin-out and translation of devices into industry and practice.  In one example, he is working with colleagues on combining ultrasonics with computational photonics to produce ultra-high resolution mobile microscopes for biological imaging, resolving objects at sub-micron resolutions on a phone camera (e.g. differentiating viruses and bacteria). In a second strand of his current work, rapid, zero-cost multiplexed “origami paper” diagnostics are being trialled in rural East Africa as species-specific DNA sensors to identify the cause of infectious disease and inform treatment amongst under-served rural communities. Further examples of translation of his research include bathroom diagnostics, sold as a bowel cancer test on the high street (e.g. Boots the Chemist), and a new venture-funded product for sexual health testing in the clinic.

Jon has given plenary talks at major international conferences including Photonics West and IEEE MEMS, for example. He was elected as a Fellow of the Royal Academy of Engineering (UK’s national academy of engineering) as well as a Fellow of the Royal Society of Edinburgh (Scotland’s national academy of arts, humanities and sciences). He has published over 260 paper, 18 books and book chapters and has an H-index of 49.

Session 1C2

Author: Patrick Doyle, MIT, USA

Presentation Title:  Microfluidic Technologies to Manufacture Soft Matter Materials

Patrick Doyle is the Robert T. Haslam Professor of Chemical Engineering at the Massachusetts Institute of Technology. His research focuses on fundamental and applied topics in soft matter. Much of his research is the area of micro/nanofluidic technologies, DNA biophysics, biosensing and nanoemulsions. A burgeoning interest is the use of microfluidics to synthesize microparticles for both fundamental colloidal studies and applications, such as multiplexed sensing, biomimetic systems and anti-counterfeiting.  He obtained his B.S.E. degree from the University of Pennsylvania in 1992, and his Ph.D. from Stanford University in 1997, working with Eric Shaqfeh and Alice Gast. After postdoctoral work with Jean-Louis Viovy at the Institute Curie in Paris, he joined the Chemical Engineering Department at MIT in 2000. Among his honors are the NSF-Career Award (2003), RSC Pioneers of Miniaturization Prize (2008), John Simon Guggenheim Fellowship (2009), and the RSC Soft Matter Lectureship (2012). He has also delivered the Colburn, Thiele and Van Ness Memorial Lectures. He is the graduate officer of the Chemical Engineering Department and has won the Michael Mohr Outstanding Faculty Award in 2013 and 2014 for his teaching of undergraduate fluid mechanics.  He has co-founded two startup companies – Firefly Bioworks (founded in 2010, acquired by Abcam in 2015) and Motif Micro (founded in 2015, acquired by YPB Systems in 2018).

Tuesday, 13 November @ 13:20 – 13:50

Session 2A2

Author: Yoon-Kyoung Cho, UNIST (Ulsan National Institute of Science & Technology), South Korea

Presentation Title: Lab-on-a-disc for Personalized Medicine

Yoon-Kyoung Cho received her Ph.D. in Materials Science and Engineering from the University of Illinois at Urbana-Champaign, USA in 1999, having obtained her M.S. and B.S. in Chemical Engineering from POSTECH, Republic of Korea in 1994 and 1992, respectively. She worked as a senior researcher (1999–2008) at Samsung Advanced Institute of Technology (SAIT) in Republic of Korea, where she participated in the development of in vitro diagnostic devices for biomedical applications. Since she joined UNIST in 2008, she has been the chair of the school of Nano-Bioscience and Chemical Engineering (2008–2014) and the school of Life Sciences (2014–2015) and the director of World Class University (2009–2013) and BK21 (2013–2015) programs. Currently she is a full professor in Biomedical Engineering at UNIST and a group leader in the Center for Soft and Living Matter at the Institute for Basic Science (IBS), Republic of Korea. She has published over 74 journal papers and over 176 granted patents. She has been an editorial board member of Lab on a Chip and an advisory board member of Analyst. She is a Fellow of the Royal Society of Chemistry (FRSC). She received several awards including Ministry commendation from the ministry of health and welfare (2017), Korean woman engineer of the year (2010), Samsung CEO’s award for best technology achievement of the year (2004, 2007). She has served as co-chair of ISMM 2018, and a technical or organizing committee member in many international conferences including MicroTAS 2015. Her research interests range from basic sciences to translational research in microfluidics and personalized medicine. Current research topics include lab-on-a-disc for liquid biopsy using circulating tumor cells and extracellular vesicles and systems analysis of cell to cell communication. http://fruits.unist.ac.kr

Session 2B2

Author: Ryuji Yokokawa, Kyoto University, Japan

Presentation Title: On-chip vascular networks for three-dimensional tissue models and organ-on-a-chip applications

Ryuji Yokokawa is an Associate Professor at Department of Micro Engineering, Kyoto University, Japan, and a Visiting Researcher at RIKEN Center for Biosystems Dynamics Research (BDR), Japan. He received his Ph.D. degree in Department of Electrical Engineering from The University of Tokyo in 2005. He received his B.S. and M.S. degrees in Department of Mechanical Engineering from Kyoto University. He was a visiting student in Prof. C.J. Kim’s group, Department of Mechanical and Aerospace Engineering, University of California, Los Angeles (2000–2001) and a visiting scholar with Prof. S. Takayama, Department of Biomedical Engineering, University of Michigan (2011–2012).

His current research areas are micro/nano fabrications for biophysics of motor proteins and on-chip vascular networks for iPS-based organ-on-a-chip (microphysiological system) applications. He has developed several molecular systems using kinesin and dynein motor proteins that enable us to visualize molecular bindings in real time (ACS Nano, 2013), to separate microtubules depending on their electro-mechanical properties (Sci. Rep., 2013, Sci. Robot., 2017), to evaluate the tug-of-war of microtubules by kinesin and dynein motors (Sci. Rep., 2014), and to visualize motors and ATP at single molecule level. Recently, his group developed an on-chip vascular network using human umbilical vein endothelial cells (HUVECs) and human lung fibroblasts (hLFs). The network provides a perfusable long-term assay of a spheroid and evaluation of angiogenic sprouts via applied shear stress (Integr. Biol., 2017, J. Vis. Exp., 2018). Based on this technology, he is currently applying the on-chip vasculature to iPS-derived organoids and organ-on-a-chip applications.

He has authored or co-authored more than 65 peer-reviewed journal and 116 conference papers, 1 book chapter, and has 5 patents issued or pending. He has served as a technical or organizing committee member in many international conferences including IEEE NEMS, MEMS, Sensors and NANOMED. He has received several academic awards such as The Young Scientists’ Prize, The Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology in 2016.

Session 2C2

Presentation Author: Amy Shen, Okinawa Institute of Technology Graduate University, Japan

Title: Novel nano – and microfabrication techniques for immunoassay and biosensor applications

Amy Shen received her Ph. D in Theoretical and Applied Mechanics from University of Illinois at Urbana Champaign in 2001. She is currently a professor in Micro/Bio/Nanofluidic Unit at Okinawa Institute of Science and Technology in Japan (https://groups.oist.jp/mbnu). She was a faculty member at Mechanical Engineering at University of Washington before moving to Japan in 2014. Professor Shen’s research is focused on rheology and microfluidics of complex fluids, and viscoelastic and inertio-elastic instabilities at small length scales, with applications in biotechnology, particularly in biosensing. Amy received Ralph E. Powe Junior Faculty Enhancement Award in 2003 and the National Science Foundation’s CAREER Award in 2007. Amy was also a Fulbright Scholar in 2013.

Wednesday, 14 November @ 14:25 – 14:55

Session 3A3

Author: Róisín M. Owens, University of Cambridge, UK

Presentation Title: The world is not flat: 3D models of human tissues integrated with 3D fluidics and electronics

Dr. Róisín M. Owens is a University Lecturer at the Dept. of Chemical Engineering and Biotechnology in the University of Cambridge, and fellow at Newnham College. She received her BA in Natural Sciences (Mod. Biochemistry) at Trinity College Dublin, and her PhD in Biochemistry and Molecular Biology at Southampton University. She carried out two postdoc fellowships at Cornell University, on host-pathogen interactions of Mycobacterium tuberculosis in the dept. of Microbiology and Immunology with Prof. David Russell, and on rhinovirus therapeutics in the dept. of Biomedical Engineering with Prof. Moonsoo Jin. From 2009-2017 she was a group leader in the dept. of bioelectronics at Ecole des Mines de St. Etienne, on the microelectronics campus in Provence. Her current research centers on application of organic electronic materials for monitoring biological systems in vitro, with a specific interest in studying the gut-brain-microbiome axis. She has received several awards including the European Research Council starting (2011), proof of concept grant (2014) and consolidator (2016) grants, a Marie Curie fellowship, and an EMBO fellowship. In 2014, she became principle editor for biomaterials for MRS communications (Cambridge University Press), and she serves on the advisory board of Advanced BioSystems and Journal of Applied Polymer Science (Wiley). She is author of 60+ publications and 2 patents.

Session 3B3

Author: Nicole Pamme, University of Hull, UK

Presentation Title: Microfluidic approaches to particle and cell separation

Nicole Pamme obtained a Diploma in Chemistry from the University of Marburg (Germany) in 1999. For her PhD studies she went to Imperial College London (UK) where she joined the group of Prof. Andreas Manz. It was here that she first started working with microfluidic devices, more specifically, on single particle analysis inside microfluidic channels. In 2004, she moved to Tsukuba (Japan) as an independent research fellow in the International Centre for Young Scientists (ICYS) based at the Japanese National Institute for Materials Science. She was appointed as a Lecturer Analytical Chemistry at the University of Hull in the UK in December 2005 and was promoted to senior lecturer in 2010, Reader in 2013 and Professor in 2014. Her research evolves around the study of microfluidic lab-on-a-chip devices for environmental analysis on-site, for clinical diagnostics at the point-of-care and the synthesis of smart materials. She has authored >100 peer reviewed publications in this area. She is a Fellow of the Royal Society of Chemistry (FRSC) and a Fellow of the Higher Education Academy (FHEA). Prof. Pamme serves on the editorial advisory boards of Lab on a Chip (RSC Publishing) and Analytica Chimica Acta (Elsevier). She chaired the MicroTAS 2016 conference in Dublin and sits on the Board of Directors of the Chemical and Biological Microsystems Society (CBMS), currently as its Vice President. Her teaching activities include lectures on microanalytical and forensic chemistry as well as biosensors; Nicole has also co-authored a textbook for UG students on Bioanalytical Chemistry, now in its second edition.

Session 3C3

Pak Kin Wong, The Pennsylvania State University, USA

Presentation Title: A Single Cell Biosensor for Probing Bladder Cancer Heterogeneity

Pak Kin Wong is a Professor of Biomedical Engineering, Mechanical Engineering, and Surgery at the Pennsylvania State University.  He received his Ph.D. from the University of California, Los Angeles in 2005.  His current research interest focuses on single cell nanobiosensors and advanced biomanufacturing strategies for biomedical applications, such as cancer metastasis and infectious diseases.  His research group has demonstrated patient-specific 3D microtumor models and has pioneered the application of dynamic single cell analysis techniques for probing collective cancer invasion.  He has published over 100 peer-reviewed journal articles in the area of nanotechnology and biomedical engineering and is an inventor of three patents.  He organizes numerous international conferences, including serving as the General Co-Chair of IEEE NEMS 2017 in Los Angeles CA and General Chair of IEEE NANOMED 2018 in Waikiki Beach HI.  He is an editor of Scientific Reports, IEEE Transaction on Nanotechnology, IEEE Nanotechnology Magazine, and SLAS Technology.  Among other honors, Dr. Wong received the NIH Director’s New Innovator Award in 2010, Arizona Engineering Faculty Fellow in 2011, AAFSAA outstanding Faculty Award in 2013, and JALA 10 – A Top 10 Breakthrough in Innovation in 2015.  Dr. Wong is a Fellow of Royal Society of Chemistry (RSC), American Institute of Medical and Biological Engineering (AIMBE), and Society for Laboratory Automation and Screening (SLAS).